On March 27, 2026, the "Regulation on Classification and Labeling of Chemical Substances" was partially amended (National Institute of Chemical Safety Notice No. 2026-6).
This amendment corrects some errors in the classification and labeling items of previously registered substances.
Overview
Key takeaways
The major changes in this notification (No. 2026-6) are twofold:
Designation of 74 new substances
Changes in the classification and labeling of 5 previously registered substances
In this article, we will focus on the updates regarding the 5 previously registered substances.
CAS No.
| Substance
| Before
| After
| Details of Change
|
|---|
97-1-3 | Urea peroxide | CAS: ' (Typo) | CAS: 124-43-6 | Correction of CAS No. error |
97-1-79 | Methyl apoxide | UN No.: 3287 | UN No.: 2810 | Change of UN No. |
97-1-381 | Sodium fluoride | Korean Name: 플루오르 나트륨 | Korean Name: 플루오르화 나트륨 | Correction of Korean Name |
97-1-417 | p-Dimethylaminobenzenediazosulfonic acid salts | Single substance name, CAS: 150-70-9 | Expanded to 'salts' group, CAS: - | Expansion of substance scope |
2014-1-717 | 1-Methylpyrrolidine | Pictograms: GHS02·GHS06·GHS08 | Pictograms: GHS02·GHS05·GHS06 | Change of pictograms (GHS08 removed, GHS05 added) |
Conclusion
The core of the NICS Notice No. 2026-6 is the "designation of 74 new hazardous chemicals and the modification of information for 5 previously registered substances."
While this newsletter focuses on the changes to the 5 substances that require immediate data updates in your working systems, the 74 newly designated substances are equally crucial for corporate regulatory compliance.
We highly recommend reviewing them again along with the aforementioned [Newsletter on Amendments to the Designation of Hazardous Substances].
We advise you to thoroughly check your internal data and take proactive measures to ensure the latest changes are reflected without omission.
MDSKorea will continue to do our best to provide valuable insights and compliance updates to professionals in the field. Thank you.
[Glossary]
We have selected and summarized key terms related to this newsletter.
| Term | Description |
|---|
Given No.
| A unique domestic identification number assigned to each chemical substance by the National Institute of Chemical Safety (NICS).
|
CAS No.
| A globally recognized identification number for chemical substances.
|
Skin corrosion/irritation
| The property of causing tissue damage or reversible irritation upon contact with the skin.
|
GHS Pictogram
| International standard logos that visually indicate the hazardous properties of chemical substances.
|
Acute toxicity
| Toxicity causing adverse effects following a single or short-term exposure (oral, dermal, or inhalation). (Categorized from 1 to 5; the lower the number, the higher the toxicity.)
|
Skin sensitization
| The property of potentially causing allergic contact dermatitis through an immune response upon repeated contact.
|
Hazardous to the aquatic environment
| The property of causing adverse effects to aquatic ecosystems.
|
M-factor
| A multiplying factor applied to substances that are highly toxic to the aquatic environment. |
UN No.
| A number used for the international transport of dangerous goods.
|
[References]
On March 27, 2026, the "Regulation on Classification and Labeling of Chemical Substances" was partially amended (National Institute of Chemical Safety Notice No. 2026-6).
This amendment corrects some errors in the classification and labeling items of previously registered substances.
Overview
Effective Date: March 27, 2026 (Effective from the date of notification)
Key Reference:
The previous notification was NICS Notice No. 2025-20 (August 7, 2025).
For detailed information on the designation of 74 new substances (Given No. 2026-1-1281~1354), concentration limits for determining hazardous chemicals, and phased compliance deadlines, please refer to our previously published [Newsletter on Amendments to the Designation of Hazardous Substances].
Key takeaways
The major changes in this notification (No. 2026-6) are twofold:
Designation of 74 new substances
Changes in the classification and labeling of 5 previously registered substances
In this article, we will focus on the updates regarding the 5 previously registered substances.
97-1-3
Urea peroxide
CAS: ' (Typo)
CAS: 124-43-6
Correction of CAS No. error
97-1-79
Methyl apoxide
UN No.: 3287
UN No.: 2810
Change of UN No.
97-1-381
Sodium fluoride
Korean Name:
플루오르 나트륨
Korean Name:
플루오르화 나트륨
Correction of Korean Name
97-1-417
p-Dimethylaminobenzenediazosulfonic acid salts
Single substance name, CAS: 150-70-9
Expanded to 'salts' group, CAS: -
Expansion of substance scope
2014-1-717
1-Methylpyrrolidine
Pictograms: GHS02·GHS06·GHS08
Pictograms: GHS02·GHS05·GHS06
Change of pictograms
(GHS08 removed, GHS05 added)
Conclusion
The core of the NICS Notice No. 2026-6 is the "designation of 74 new hazardous chemicals and the modification of information for 5 previously registered substances."
While this newsletter focuses on the changes to the 5 substances that require immediate data updates in your working systems, the 74 newly designated substances are equally crucial for corporate regulatory compliance.
We highly recommend reviewing them again along with the aforementioned [Newsletter on Amendments to the Designation of Hazardous Substances].
We advise you to thoroughly check your internal data and take proactive measures to ensure the latest changes are reflected without omission.
MDSKorea will continue to do our best to provide valuable insights and compliance updates to professionals in the field. Thank you.
[Glossary]
We have selected and summarized key terms related to this newsletter.
[References]
Original Source: NICS Notice No. 2026-6 & 2025-20 (Available on the NICS website)
Attachments: Revised Classification List (Excel) & Amendment Details (PDF)